Endocrine Abstracts

Objective: Intriguing studies suggest that osteocalcin (OC) and its carboxylated (Gla)/uncarboxylated form are involved in the regulation of insulin secretion and action. Additionally, advanced glycated end products (AGEs), directly regulate the secretion of these osteoblast derived molecules. In PCOS among the pathophysiological aberrations, deregulation of insulin secretion and action as well as elevated AGEs levels have been demonstrated. In this study, we evaluated the ser...

Background: Chronic anovulation constitutes one of the cardinal features of Polycystic Ovary Syndrome (PCOS) and Anti-Müllerian hormone (AMH), a granulosa cell product, is a well documented marker of anovulation. Recent data have shown that oxidative stress is involved in the pathophysiology of anovulation. A marker of oxidative stress, Advanced Glycosylated End products (AGEs), is implicated to the pathogenesis of the syndrome and have been localized with high intensity ...

Background: Conflicting results regarding adiponectin levels in women with polycystic ovary syndrome (PCOS) have been reported. To evaluate adiponectin levels in PCOS, a systematic review of all studies comparing adiponectin levels in women with PCOS to healthy controls and a meta-analysis of those involving women with similar Body Mass Index (BMI) were performed. Influence of possible effect modifiers, such as insulin resistance (IR) and testosterone, was investigated. Influe...

In insulin resistant, young women with PCOS elevated serum AGEs and their receptor RAGE have been reported. The present study (approved by the local ethical committee) was undertaken to determine whether increased levels of serum AGEs in PCOS is a distinct finding compared with age- and BMI-matched women, presenting the isolated components of the syndrome and whether serum AGE levels were different among PCOS phenotypes. A total of 193 lean non-insulin resistant women were stu...

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder. The metabolic aspect of disorder is characterized by obesity-related risk factors for cardiovascular disease. The aim of this study was to determine in women with PCOS, indices of lipid metabolism and their oxidation, and to assess possible relation to insulin resistance. We investigated 75 women with PCOS (age: 23.1±5.1 years, body mass index (BMI): 24.9±4.7 kg/m2) and 56 age an...

Introduction: There is a link between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD). Here, we analyzed transaminazes and their relation to insulin resistance (IR) in PCOS women.Methods: We analyzed 600 women with PCOS diagnosed using ESHRE/ASRM criteria (age:25.6±5.9 years, BMI: 30.6±6.9 kg/m2), and 125 BMI-matched healthy controls (age: 31.4±5.3 years, BMI: 29.6±6.8 kg/m2). IR was...

Introduction: The polycystic ovary syndrome (PCOS) is a common and complex disease without a clear pattern of inheritance. There is evidence that PCOS is affected by both genetic and environmental factors, but there is no single and unambiguous explanation for its pathogenesis. Anti-Müllerian-inhibiting hormone (AMH) has an inhibitory effect on FSH-stimulated follicle growth and it has also been shown that serum AMH levels are higher in women with PCOS than in normovulato...

Background: Polycystic ovary syndrome (PCOS) is associated with obesity and insulin resistance, two major contributors to cardiovascular risk. Even in the absence of detectable insulin resistance, lean, non-diabetic PCOS women demonstrate increased circulating levels of advanced glycated end products (AGEs), known proatherogenic molecules. This adverse cardiovascular risk profile should be considered in the syndrome’s management.Objective: To invest...

Objective: Polycystic ovary syndrome (PCOS) is hypothesized to originate in foetal life, while its long-term consequences extend beyond menopause. However, the natural course of the disorder has not as yet been elucidated, and recent data suggest differences in the evolution of PCOS according to a woman’s weight. We aimed to define the evolution of normal-weight Caucasian women with PCOS through the years.Design: Cross-sectional case control study</...

Introduction: Women with PCOS have increased risk for non-alcoholic fatty liver disease (NAFLD). Alanine aminotransferase (ALT) is a sensitive indicator of liver cell injury. The aim of this study is to determine levels of liver enzymes in normal-weight women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Normal weight was defined as BMI ≤25 kg/m2. We evaluated 62 normal weight women with PCOS (PCOS group: 20.99±1....